Pearls
You can either purchase pearls in the shop or earn them through all types of quests.
In the game, pearls can be used for the following actions:
Skip construction times for buildings and upgrades
Buy manifests
Buy a 4th manifest slot
Reroll workers
Gems
Gems cannot be purchased directly. You receive them by destroying manifests or through all types of quests.
Gems can be used to:
Extend manifests
Extend personalities